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The PAIR Center’s inclusive, impactful, and innovative research improves clinical practice and heath care policy.

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The PAIR Center brings together mission-driven faculty, staff, trainees and advisors who are committed to high-quality science and improving how we care for seriously ill patients.

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The PAIR Center is committed to forging multidisciplinary partnerships within Penn and the surrounding West Philadelphia community, and across the nation.

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Discover the latest in PAIR Center news, events, awards, and announcements.

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About
We generate high-quality evidence to advance healthcare policies and practices with the goal of improving the lives of all people affected by serious illness and removing the barriers to health equity that seriously ill patients commonly face.

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Publications

Explore selected publications to gain a deeper understanding of our work.

Close-up of Dr. Rachel Kohn at podium during the 2022 Roybal Retreat

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Effects of an early restrictive versus liberal fluid strategy on long-term patient-centered outcomes in sepsis-induced hypotension (SHAMROC): An open-label, randomized controlled trial

American Journal of Respiratory and Critical Care Medicine

May 6, 2026

PAIR Center Research Team

Casey Whitman

Zhe Chen

Michael Harhay

Catherine Auriemma

Supporting Evidence-based Responses to Emotional Needs in Emphysema (SERENE): Protocol for a randomized, open-label mechanistic trial comparing Coping Skills Training and disease-specific education for depressive symptoms conducted in United States health systems

TRIALS

February 25, 2026

PAIR Center Research Team

Joanna Hart

Dan Carter

Chloe Hinton

Lily Brown

Nora Brier

Yingying Lu

Casey Whitman

Michael Harhay

Carmen Alvarez

Measuring goal-concordant care using electronic clinical notes

JAMA Network Open

July 3, 2025

PAIR Center Research Team

Catherine Auriemma

Anne Song

Stefania Scott

Casey Whitman

Gary Weissman

Kate Courtright

A series of randomized trials of behavioral economic interventions to increase racial and ethnic diversity of research participants: Rationale and design of ITERATE

American Heart Journal

March 29, 2025

PAIR Center Research Team

Nirali Patel

Casey Whitman

Adina Lieberman

Shira Blady

Rachel Kohn

Kevin Volpp

Scott Halpern

Alisa Stephens-Shields

Alexander Fanaroff

Nudging clinicians to promote serious illness communication for critically ill patients: A pragmatic cluster randomized trial

JAMA Internal Medicine

March 17, 2025

PAIR Center Research Team

Kate Courtright

Erich Dress

Brian Bayes

Michael Harhay

Yingying Lu

Dylan Small

Casey Whitman

Jenny Tian

Vanessa Madden

Scott Halpern

Classification of documented goals of care among hospitalized patients with high mortality risk: A mixed-methods feasibility study

Journal of General Internal Medicine

May 6, 2024

PAIR Center Research Team

Catherine Auriemma

Anne Song

Stefania Scott

Casey Whitman

Scott Halpern

Kate Courtright

Default palliative care consultation for seriously ill hospitalized patients: A pragmatic cluster randomized trial

JAMA

January 16, 2024

PAIR Center Research Team

Kate Courtright

Vanessa Madden

Brian Bayes

Casey Whitman

Dylan Small

Michael Harhay

Elizabeth Cooney-Zingman

Scott Halpern

Accuracy of expected symptoms and subsequent quality of life measures among adults with COPD

JAMA Network Open

November 21, 2023

PAIR Center Research Team

Joanna Hart

Casey Whitman

Bryan Blette

Michael Harhay

Scott Halpern

Structured mobilization for critically ill patients: A pragmatic cluster-randomized trial

American Journal of Respiratory and Critical Care Medicine

July 1, 2023

PAIR Center Research Team

William Schweickert

Juliane Jablonski

Brian Bayes

Casey Whitman

Jenny Tian

Bryan Blette

Scott Halpern

Moving “OurCareWishes” to the bedside: A step-wedge pragmatic trial

Journal of Pain and Symptom Management

May 17, 2022

PAIR Center Research Team

Christopher Jones

Casey Whitman