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The PAIR Center’s inclusive, impactful, and innovative research improves clinical practice and heath care policy.

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The PAIR Center brings together mission-driven faculty, staff, trainees and advisors who are committed to high-quality science and improving how we care for seriously ill patients.

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The PAIR Center is committed to forging multidisciplinary partnerships within Penn and the surrounding West Philadelphia community, and across the nation.

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Discover the latest in PAIR Center news, events, awards, and announcements.

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We generate high-quality evidence to advance healthcare policies and practices with the goal of improving the lives of all people affected by serious illness and removing the barriers to health equity that seriously ill patients commonly face.

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Publications

Explore selected publications to gain a deeper understanding of our work.

Close-up of Dr. Rachel Kohn at podium during the 2022 Roybal Retreat

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Nudging implementation of low tidal volume ventilation: A stepped wedge, cluster randomized trial

Implementation Science

May 7, 2026

PAIR Center Research Team

Meeta Prasad Kerlin

Michael Harhay

Dylan Small

Yingying Lu

Barry Fuchs

Aerielle Belk

Jasmine Silvestri

Tamar Klaiman

Stefania Scott

Elizabeth Levy

Rachel Kohn

Scott Halpern

Supporting Evidence-based Responses to Emotional Needs in Emphysema (SERENE): Protocol for a randomized, open-label mechanistic trial comparing Coping Skills Training and disease-specific education for depressive symptoms conducted in United States health systems

TRIALS

February 25, 2026

PAIR Center Research Team

Joanna Hart

Dan Carter

Chloe Hinton

Lily Brown

Nora Brier

Yingying Lu

Casey Whitman

Michael Harhay

Carmen Alvarez

Evaluating AI-based comprehensive clinical decision support for sepsis and ARDS: Protocol for a Clinician Turing Test

BMJ Open

December 24, 2025

PAIR Center Research Team

Antonia Angeli Gazola

Nicholas Bishop

Benjamin Schmid

Dustin Krutsinger

Yingying Lu

Lyle Ungar

Nuala Meyer

Meeta Prasad Kerlin

Gary Weissman

Nudging clinicians to promote serious illness communication for critically ill patients: A pragmatic cluster randomized trial

JAMA Internal Medicine

March 17, 2025

PAIR Center Research Team

Kate Courtright

Erich Dress

Brian Bayes

Michael Harhay

Yingying Lu

Dylan Small

Casey Whitman

Jenny Tian

Vanessa Madden

Scott Halpern

Patient dignity in long-term recovery among survivors of acute respiratory failure: A prospective cohort study

American Journal of Respiratory and Critical Care Medicine

March 4, 2025

PAIR Center Research Team

Rachel Kohn

Craig Kwiatkowski

Yingying Lu

Erich Dress

Stefania Scott

Michael Harhay